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Kelch Like ECH Associated Protein 1 (KEAP1)

INrf2; KLHL19; Cytosolic inhibitor of Nrf2; Kelch-like protein 19

KEAP1 encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.Kelch motifs of Keap1 interact with the Neh2 domain of Nrf2 and that this interaction is required for the repression of Nrf2 by Keap1. Fluorescence microscopy demonstrated that Keap1 is expressed in the cytoplasm with Nrf2.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins M742Hu01 Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies MM742Hu21 Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
PM742Hu01 Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits KEM742Hu ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins M742Mu01 Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
PM742Mu01 Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits KEM742Mu ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Kelch Like ECH Associated Protein 1 (KEAP1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Kelch Like ECH Associated Protein 1 (KEAP1) Bioactivity
Antibodies NONE Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Kelch Like ECH Associated Protein 1 (KEAP1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Kelch Like ECH Associated Protein 1 (KEAP1) CLIA assay for Antigen Detection

Reference

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"Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress."
Mol. Cell. Biol. 23:8137-8151(2003) [PubMed] [Europe PMC] [Abstract]

"Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein."
Biochemistry 43:12113-12122(2004) [PubMed] [Europe PMC] [Abstract]

"Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex."
Mol. Cell. Biol. 24:10941-10953(2004) [PubMed] [Europe PMC] [Abstract]

"Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway."
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"Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes."
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"Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function."
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"PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex."
J. Biol. Chem. 281:37893-37903(2006) [PubMed] [Europe PMC] [Abstract]

"PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria."
Exp. Cell Res. 314:1789-1803(2008) [PubMed] [Europe PMC] [Abstract]

"Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level."
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"Initial characterization of the human central proteome."
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"Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites."
Nature 502:254-257(2013) [PubMed] [Europe PMC] [Abstract]

"Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1."
Acta Crystallogr. D 60:2346-2348(2004) [PubMed] [Europe PMC] [Abstract]

"Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1."
Acta Crystallogr. D 61:1335-1342(2005) [PubMed] [Europe PMC] [Abstract]

"Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling."
EMBO J. 25:3605-3617(2006) [PubMed] [Europe PMC] [Abstract]

"Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer."
Mol. Cell 21:689-700(2006) [PubMed] [Europe PMC] [Abstract]

"Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer."
PLoS Med. 3:1865-1876(2006) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
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