Microtubule Associated Protein 1 Light Chain 3 Alpha (MAP1LC3a)

MAP1ALC3; MAP1BLC3; LC3; LC3A; ATG8E; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1

SPN	M690
HGNC	6838
MGI	1915661
PubMed	19623642
RGD	735183
UniProt	Q9H492
Wiki	MAP1LC3A

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene.

The deduced 121-amino acid protein shares 81% identity with rat Map1lc3. Northern blot analysis detected a 1.1-kb transcript in most tissues examined, with highest expression in heart, brain, liver, skeletal muscle, and testis. No MAP1LC3A expression was detected in thymus and peripheral blood leukocytes.

Reference

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J. Biol. Chem. 278:29278-29287(2003) [PubMed] [Europe PMC] [Abstract]

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BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

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Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
J. Biol. Chem. 276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]

"Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
J. Biol. Chem. 277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]

"HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates."
J. Biol. Chem. 279:36268-36276(2004) [PubMed] [Europe PMC] [Abstract]

"p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy."
J. Biol. Chem. 282:24131-24145(2007) [PubMed] [Europe PMC] [Abstract]

"The TP53INP2 protein is required for autophagy in mammalian cells."
Mol. Biol. Cell 20:870-881(2009) [PubMed] [Europe PMC] [Abstract]

"Regulation of the autophagy protein LC3 by phosphorylation."
J. Cell Biol. 190:533-539(2010) [PubMed] [Europe PMC] [Abstract]

"TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death."
Cell Death Differ. 19:1525-1535(2012) [PubMed] [Europe PMC] [Abstract]

"ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs."
J. Biol. Chem. 287:39275-39290(2012) [PubMed] [Europe PMC] [Abstract]

"Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers."
Mol. Cell. Biol. 32:1733-1744(2012) [PubMed] [Europe PMC] [Abstract]

"DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription."
PLoS ONE 7:E34034-E34034(2012) [PubMed] [Europe PMC] [Abstract]

"The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation."
Science 338:1072-1076(2012) [PubMed] [Europe PMC] [Abstract]