Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 (MAP3K7IP1)

TAB1; TGF-Beta Activated Kinase 1/MAP3K7 Binding Protein 1; TAK1-Binding Protein 1; TGF-beta-activated kinase 1-binding protein 1

SPN	M686
HGNC	18157
MGI	1913763
PubMed	8638164
UniProt	Q15750
Wiki	MAP3K7IP1

MAP3K7IP1was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli.

Reference

"TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction."
Science 272:1179-1182(1996) [PubMed] [Europe PMC] [Abstract]

"TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1."
J. Biol. Chem. 278:2286-2293(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway."
Nature 398:252-256(1999) [PubMed] [Europe PMC] [Abstract]

"TAK1 is a ubiquitin-dependent kinase of MKK and IKK."
Nature 412:346-351(2001) [PubMed] [Europe PMC] [Abstract]

"The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway."
EMBO Rep. 7:838-844(2006) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"TAK1-binding protein 1 is a pseudophosphatase."
Biochem. J. 399:427-434(2006) [PubMed] [Europe PMC] [Abstract]

"XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization."
Mol. Cell 26:689-702(2007) [PubMed] [Europe PMC] [Abstract]