Ring Finger And KH Domain Containing Protein 1 (RKHD1)

MEX3D; MEX3; TINO; RNF193; Mex-3 Homolog D; Bcl-2 ARE RNA Binding Protein; RING finger protein 193; RNA-binding protein MEX3D

SPN	M672
HGNC	16734
MGI	2681847
PubMed	14769789
RGD	1310576
UniProt	Q86XN8
Wiki	MEX3D

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs and a RING domain at the C-terminus.The predicted 490-amino acid partial protein has 2 N-terminal ribonucleoprotein K homology (KH) domains and a C-terminal RING domain, and it shares similarity with C. elegans Mex3. Northern blot analysis detected a 3.1-kb transcript in all tissues examined, with highest expression in placenta. A 6.5-kb transcript was also present in heart and skeletal muscle. Immunofluorescence analysis of HeLa cells localized endogenous TINO predominantly in the nucleus and perinuclear region.

Reference

"Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies."
Nucleic Acids Res. 35:1289-1300(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein."
J. Biol. Chem. 279:20154-20166(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the second KH domain in RING finger and KH domain-containing protein 1."
Submitted (SEP-2006) to the PDB data bank