MYC Induced Nuclear Antigen (MINA)

MDIG; NO52; MINA53; ROX; Mineral dust-induced gene protein; Nucleolar protein 52; 60S ribosomal protein L27a histidine hydroxylase; Ribosomal oxygenase MINA

SPN	M663
HGNC	19441
MGI	1914264
PubMed	12091391
RGD	708521
UniProt	Q8IUF8
Wiki	MINA

The deduced 465-amino acid protein has a calculated molecular mass of 52.7 kD. Additional alternative splice forms were isolated and correspond to a deduced protein of 464 amino acids lacking gln297 and a species containing a 101-bp insertion, deduced to contain the N-terminal 262 amino acids followed by 18 novel residues.

MINA shares 72% and 75% amino acid identity with the corresponding mouse and rat orthologs, respectively. Immunofluorescence studies localized MINA to the nucleus in a diffuse pattern with some distribution in a strong dotted staining pattern, corresponding to a nucleolar localization. Northern blot analysis detected a 5-fold increase in MINA expression after serum stimulation of serum-starved T98G glioblastoma cells.

Reference

"A novel myc target gene, mina53, that is involved in cell proliferation."
J. Biol. Chem. 277:35450-35459(2002) [PubMed] [Europe PMC] [Abstract].

"NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin."
Mol. Biol. Cell 15:1816-1832(2004) [PubMed] [Europe PMC] [Abstract]

"The human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer."
Oncogene 24:4873-4882(2005) [PubMed] [Europe PMC] [Abstract] and Lung cancer.

"MDIG gene, a potential biomarker for human lung cancer."
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Increased expression of a Myc target gene Mina53 in human colon cancer."
Am. J. Pathol. 164:205-216(2004) [PubMed] [Europe PMC] [Abstract]

"Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma."
Clin. Cancer Res. 10:7347-7356(2004) [PubMed] [Europe PMC] [Abstract]

"Protein NO52 -- a constitutive nucleolar component sharing high sequence homologies to protein NO66."
Eur. J. Cell Biol. 84:279-294(2005) [PubMed] [Europe PMC] [Abstract]

"Immunohistochemical expression of Mina53 and Ki67 proteins in human primary gingival squamous cell carcinoma."
Kurume Med. J. 53:71-78(2006) [PubMed] [Europe PMC] [Abstract]

"Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3."
Cell Cycle 8:2101-2109(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans."
Nat. Chem. Biol. 8:960-962(2012) [PubMed] [Europe PMC] [Abstract]