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MutL Homolog 3 (MLH3)
MutL Homolog 3 (MLH3)
HNPCC7; DNA mismatch repair protein Mlh3
MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). MLH3 is more similar to mismatch repair proteins from yeast, plants, worms, and bacteria than to any known mammalian protein, suggesting that its conserved sequence may confer unique functions in mice and humans. Cells in culture stably expressing a dominant-negative MLH3 protein exhibited microsatellite instability.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
KEM657Hu
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant MutL Homolog 3 (MLH3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native MutL Homolog 3 (MLH3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to MutL Homolog 3 (MLH3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to MutL Homolog 3 (MLH3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for MutL Homolog 3 (MLH3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for MutL Homolog 3 (MLH3) CLIA assay for Antigen Detection
Reference
"MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability." Nat. Genet. 24:27-35(2000) [PubMed ] [Europe PMC ] [Abstract ]
"The interacting domains of three MutL heterodimers in man: hMLH1 interacts with 36 homologous amino acid residues within hMLH3, hPMS1 and hPMS2." Nucleic Acids Res. 29:1695-1702(2001) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed ] [Europe PMC ] [Abstract ]
"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease." Nature 375:754-760(1995) [PubMed ] [Europe PMC ] [Abstract ]
"Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: evidence for somatic mutation in colorectal cancers." Hum. Mutat. 17:389-396(2001) [PubMed ] [Europe PMC ] [Abstract ]
"A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair." Mol. Cell 39:36-47(2010) [PubMed ] [Europe PMC ] [Abstract ]
"A role for MLH3 in hereditary nonpolyposis colorectal cancer." Nat. Genet. 29:137-138(2001) [PubMed ] [Europe PMC ] [Abstract ]
