Aminoacyl tRNA Synthetase Complex Interacting Multifunctional Protein 1 (AIMP1)

SCYE1; EMAP II; EMAP2; p43; Small Inducible Cytokine Subfamily E,Member 1; Endothelial monocyte-activating polypeptide II; Multisynthase complex auxiliary component p43

SPN	M632
HGNC	10648
MGI	102774
PubMed	22472603
RGD	620466
UniProt	Q12904

AIMP1 is a cytokine that is specifically induced by apoptosis. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex. Therefore, pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.EMAPII is identical to the p43 subunit invariably associated with 9 aminoacyl-tRNA synthetase complexes. They stated that the C-terminal domain of p43 is an RNA-binding domain. EMAPII may be a bifunctional protein, binding RNA as part of the tRNA synthetase complexes and, after proteolytic cleavage in tumor cells, stimulating inflammatory responses.

Reference

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