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Presenilin Associated Metalloprotease (PAMP)

FTSH; MEG4; YME1L1; YME1L; ATP-dependent metalloprotease FtsH1; YME1 Like Protein 1; ATP-dependent zinc metalloprotease YME1L1

YME1L1 is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Two transcript variants encoding different isoforms have been found for this gene.
YME1L1 shares 50% sequence identity with yeast Yme1, 40% identity with yeast Rca1, and 39% identity with yeast Afg3, with highest homology in the central regions of the proteins. Northern blot analysis revealed transcripts of about 2.6 and 4.4 kb in all tissues examined, with greatest abundance in adult heart, skeletal muscle, and pancreas.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits KEM588Hu ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Presenilin Associated Metalloprotease (PAMP) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Presenilin Associated Metalloprotease (PAMP) Bioactivity
Antibodies NONE Monoclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Presenilin Associated Metalloprotease (PAMP) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Presenilin Associated Metalloprotease (PAMP) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Presenilin Associated Metalloprotease (PAMP) CLIA assay for Antigen Detection

Reference

"Identification and characterization of YME1L1, a novel paraplegin-related gene."
Genomics 66:48-54(2000) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential."
Biol. Cell 100:315-325(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation."
Mol. Biol. Cell 23:1010-1023(2012) [PubMed] [Europe PMC] [Abstract]