Nei Endonuclease VIII Like Protein 1 (NEIL1)

NEI1; hFPG1; FPG1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Nei-like protein 1; DNA glycosylase/AP lyase Neil1

SPN	M478
HGNC	18448
MGI	1920024
PubMed	11904416
RGD	1306077
UniProt	Q96FI4
Wiki	NEIL1

NEIL1 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.

Bacterial Fpg/Nei proteins contain 2 structural domains: an N-terminal 2-layered beta sandwich and a C-terminal 4-helix bundle, which includes a helix-2-turns-helix (H2TH) motif and a zinc finger. The deduced 390-amino acid human NEIL1 protein has conserved residues in 6 highly conserved regions that span both structural domains of the bacterial Fpg/Nei proteins, but it lacks the characteristic zinc finger motif.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM478Hu01	Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM478Hu01	Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IP.
Antibodies	PAM478Hu01	Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IF.
Assay Kits	CLM478Hu01	CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	CLIA assay for Antigen Detection
Assay Kits	ELM478Hu01	ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM478Mu01	Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM478Mu01	Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IP.
Antibodies	PAM478Mu01	Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IF.
Assay Kits	CLM478Mu01	CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	CLIA assay for Antigen Detection
Assay Kits	ELM478Mu01	ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM478Ra01	Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM478Ra01	Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IP.
Antibodies	PAM478Ra01	Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IF.
Assay Kits	CLM478Ra01	CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	CLIA assay for Antigen Detection
Assay Kits	ELM478Ra01	ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM478Ca01	Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM478Ca01	Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IP.
Antibodies	PAM478Ca01	Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IF.
Assay Kits	CLM478Ca01	CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	CLIA assay for Antigen Detection
Assay Kits	ELM478Ca01	ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM478Po01	Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM478Po01	Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IP.
Antibodies	PAM478Po01	Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IF.
Assay Kits	CLM478Po01	CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	CLIA assay for Antigen Detection
Assay Kits	ELM478Po01	ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM478Bo01	Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM478Bo01	Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IP.
Antibodies	PAM478Bo01	Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IF.
Assay Kits	CLM478Bo01	CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	CLIA assay for Antigen Detection
Assay Kits	ELM478Bo01	ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM478Rb01	Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM478Rb01	Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IP.
Antibodies	PAM478Rb01	Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IF.
Assay Kits	CLM478Rb01	CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	CLIA assay for Antigen Detection
Assay Kits	ELM478Rb01	ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM478Mo01	Recombinant Nei Endonuclease VIII Like Protein 1 (NEIL1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM478Mo01	Monoclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IP.
Antibodies	PAM478Mo01	Polyclonal Antibody to Nei Endonuclease VIII Like Protein 1 (NEIL1)	WB; IHC; ICC; IF.
Assay Kits	CLM478Mo01	CLIA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	CLIA assay for Antigen Detection
Assay Kits	ELM478Mo01	ELISA Kit for Nei Endonuclease VIII Like Protein 1 (NEIL1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue."
J. Biol. Chem. 277:42205-42213(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII."
DNA Repair 1:517-529(2002) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA."
Proc. Natl. Acad. Sci. U.S.A. 99:3523-3528(2002) [PubMed] [Europe PMC] [Abstract]

"Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2."
J. Biol. Chem. 278:49679-49684(2003) [PubMed] [Europe PMC] [Abstract]

"Human NEIL1 localizes with the centrosomes and condensed chromosomes during mitosis."
DNA Repair 6:1425-1433(2007) [PubMed] [Europe PMC] [Abstract]

"RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1."
Proc. Natl. Acad. Sci. U.S.A. 107:20715-20719(2010) [PubMed] [Europe PMC] [Abstract]

"The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity."
Proc. Natl. Acad. Sci. U.S.A. 101:10284-10289(2004) [PubMed] [Europe PMC] [Abstract]

"Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome."
Kidney Int. 80:389-396(2011) [PubMed] [Europe PMC] [Abstract]