Neogenin 1 (NEO1)

NGN; IGDCC2; Immunoglobulin Superfamily,DCC Subclass Member 2

SPN	M459
HGNC	7754
MGI	1097159
PubMed	9121761
RGD	619837
UniProt	Q92859
Wiki	NEO1

NEO1 encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. NGN transcripts of about 7.5 and 5.5 kb were detected in all adult tissues studied. In contrast to the frequent loss of DCC expression in cancers, no alterations in NGN expression were observed in more than 50 cancers studied, including glioblastoma, medulloblastoma, neuroblastoma, colorectal, breast, cervical, and pancreatic cancer cell lines, and xenografts.

Reference

"Identification and characterization of neogenin, a DCC-related gene."
Oncogene 14:1129-1136(1997) [PubMed] [Europe PMC] [Abstract]

"Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3-q23."
Genomics 41:414-421(1997) [PubMed] [Europe PMC] [Abstract]

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Neogenin: A multi-functional receptor regulating diverse developmental processes."
Int. J. Biochem. Cell Biol. 39:1569-1575(2007) [PubMed] [Europe PMC] [Abstract]

"Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin."
Am. J. Physiol. 294:C994-C1003(2008) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Neogenin, a receptor for bone morphogenetic proteins."
J. Biol. Chem. 286:5157-5165(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"The solution structure of the six fibronectin type III domains of human neogenin."
Submitted (NOV-2005) to the PDB data bank