Neurofascin (NFASC)

NF; NRCAML

SPN	M458
HGNC	29866
MGI	104753
PubMed	23884033
RGD	620911
UniProt	O94856
Wiki	Neurofascin

NFASC encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin.

This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	M458Hu01	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	MM458Hu21	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	PM458Hu01	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	KEM458Hu	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Neurofascin (NFASC)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Neurofascin (NFASC)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Neurofascin (NFASC)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Neurofascin (NFASC)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Neurofascin (NFASC)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Neurofascin (NFASC)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Neurofascin (NFASC)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Neurofascin (NFASC)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Neurofascin (NFASC)	CLIA assay for Antigen Detection

Reference

"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Alternative splice variants encoding unstable protein domains exist in the human brain."
J. Mol. Biol. 343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]

"Homophilic adhesion mechanism of neurofascin, a member of the L1 family of neural cell adhesion molecules."
J. Biol. Chem. 286:797-805(2011) [PubMed] [Europe PMC] [Abstract]