Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2)

NFAT1; NFATP; NF-ATP; NFAT pre-existing subunit; T-cell transcription factor NFAT1

SPN	M455
HGNC	7776
MGI	102463
PubMed	19318479
RGD	1307690
UniProt	Q13469
Wiki	NFATC2

NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.A truncated form of NFATP, expressed as a recombinant protein in bacteria, bound specifically to the NFAT site of the murine IL2 promoter and formed a transcriptionally active complex with recombinant FOS and JUN.

Reference

"Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes."
Mol. Cell. Biol. 16:3955-3966(1996) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing and expression of human and mouse NFAT genes."
Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT."
Cell 96:611-614(1999) [PubMed] [Europe PMC] [Abstract]

"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]

"Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells."
Proc. Natl. Acad. Sci. U.S.A. 102:5138-5143(2005) [PubMed] [Europe PMC] [Abstract]

"Nine-amino-acid transactivation domain: establishment and prediction utilities."
Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"NFAT promotes carcinoma invasive migration through glypican-6."
Biochem. J. 440:157-166(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]