Protein Kinase, cAMP Dependent Catalytic Alpha (PRKACa)

PKACA

SPN	M336
HGNC	9380
MGI	97592
PubMed	24700472
RGD	3389
UniProt	P17612
Wiki	PRKACA

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the AMP-activated protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans.

PRKACais a member of the Ser/Thr protein kinase family and is a catalytic subunit of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Reference

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Submitted (JUL-2010) to the PDB data bank

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Submitted (SEP-2010) to the PDB data bank

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