Ribosomal Protein S6 Kinase Alpha 1 (RPS6Ka1)

HU-1; MAPKAPK1A; RSK; RSK1; S6K-alpha 1; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a; Ribosomal S6 kinase 1

SPN	M313
HGNC	10430
MGI	104558
PubMed	8141249
RGD	620675
UniProt	Q15418
Wiki	RPS6KA1

RPS6Ka1 encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

The HU1 cDNA encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. Northern blot and RNase protection analyses detected an approximately 3.5-kb HU1 transcript in lymphocytes, skeletal muscle, liver, and adipose tissue.

Reference

"Human rsk isoforms: cloning and characterization of tissue-specific expression."
Am. J. Physiol. 266:C351-C359(1994) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB."
EMBO J. 17:4426-4441(1998) [PubMed] [Europe PMC] [Abstract]

"Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK."
J. Biol. Chem. 273:1496-1505(1998) [PubMed] [Europe PMC] [Abstract]

"Rsk1 mediates a MEK-MAP kinase cell survival signal."
Curr. Biol. 10:127-135(2000) [PubMed] [Europe PMC] [Abstract]

"C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival."
Mol. Cell 8:807-816(2001) [PubMed] [Europe PMC] [Abstract]

"Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A."
J. Biol. Chem. 277:42669-42679(2002) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity."
Mol. Cell. Biol. 23:4796-4804(2003) [PubMed] [Europe PMC] [Abstract]

"90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling."
J. Biol. Chem. 279:29325-29335(2004) [PubMed] [Europe PMC] [Abstract]

"Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase."
Proc. Natl. Acad. Sci. U.S.A. 101:13489-13494(2004) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling."
Curr. Biol. 15:1762-1767(2005) [PubMed] [Europe PMC] [Abstract]

"Nur77 is phosphorylated in cells by RSK in response to mitogenic stimulation."
Biochem. J. 393:715-724(2006) [PubMed] [Europe PMC] [Abstract]

"The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity."
EMBO J. 25:2781-2791(2006) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation."
J. Biol. Chem. 282:14056-14064(2007) [PubMed] [Europe PMC] [Abstract]

"Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation."
Curr. Biol. 18:1269-1277(2008) [PubMed] [Europe PMC] [Abstract]

"The RSK factors of activating the Ras/MAPK signaling cascade."
Front. Biosci. 13:4258-4275(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"The RSK family of kinases: emerging roles in cellular signalling."
Nat. Rev. Mol. Cell Biol. 9:747-758(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors."
Protein Sci. 16:2626-2635(2007) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]