V-Ral Simian Leukemia Viral Oncogene Homolog A (RALA)

RAL; RAS-Like Protein A; Ras-Related Protein Ral-A; Ras Family Small GTP Binding Protein RALA

SPN	M301
HGNC	9839
MGI	1927243
PubMed	15950903
RGD	619851
UniProt	P11233
Wiki	RALA

RALA belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins.

Cancer-associated A-beta mutants failed to reverse this tumorigenic phenotype, indicating that the mutants functioned as null alleles. Cancer-derived A-beta mutants failed to form a complex with the small GTPase RALA, whereas wildtype A-beta-containing complexes dephosphorylated RALA at ser183 and ser194, inactivating RALA and abolishing its transforming function.

Reference

"Coding sequences of human ralA and ralB cDNAs."
Nucleic Acids Res. 17:4380-4380(1989) [PubMed] [Europe PMC] [Abstract]

"Identification of the ral and rac1 gene products, low molecular mass GTP-binding proteins from human platelets."
J. Biol. Chem. 264:16383-16389(1989) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA."
J. Biol. Chem. 266:9786-9794(1991) [PubMed] [Europe PMC] [Abstract]

"Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity."
J. Biol. Chem. 270:22473-22477(1995) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral."
J. Biol. Chem. 275:13406-13410(2000) [PubMed] [Europe PMC] [Abstract]

"Ral GTPases regulate exocyst assembly through dual subunit interactions."
J. Biol. Chem. 278:51743-51748(2003) [PubMed] [Europe PMC] [Abstract]

"Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth."
Mol. Cell. Biol. 27:8003-8014(2007) [PubMed] [Europe PMC] [Abstract]

"Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs."
EMBO J. 27:2375-2387(2008) [PubMed] [Europe PMC] [Abstract]

"Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK."
Cell. Signal. 21:1207-1217(2009) [PubMed] [Europe PMC] [Abstract]

"RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling."
Curr. Biol. 20:75-79(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase."
EMBO J. 24:2064-2074(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme."
EMBO J. 24:3670-3680(2005) [PubMed] [Europe PMC] [Abstract]

"Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase."
Proc. Natl. Acad. Sci. U.S.A. 102:5357-5362(2005) [PubMed] [Europe PMC] [Abstract]