Related To Receptor Tyrosine Kinase (RYK)
JTK5; JTK5A; RYK1; JTK5A Protein Tyrosine Kinase
Ryk is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains.
This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.RYK is composed of three domains, an N-terminal domain, an extracellular ligand binding domain, a transmembrane spanning domain and a C-terminal intracellular domain.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM269Hu01 | Recombinant Related To Receptor Tyrosine Kinase (RYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM269Hu01 | Monoclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IP. |
| PAM269Hu01 | Polyclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM269Hu01 | CLIA Kit for Related To Receptor Tyrosine Kinase (RYK) | CLIA assay for Antigen Detection |
| ELM269Hu01 | ELISA Kit for Related To Receptor Tyrosine Kinase (RYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM269Mu01 | Recombinant Related To Receptor Tyrosine Kinase (RYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM269Mu01 | Monoclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IP. |
| PAM269Mu01 | Polyclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM269Mu01 | CLIA Kit for Related To Receptor Tyrosine Kinase (RYK) | CLIA assay for Antigen Detection |
| ELM269Mu01 | ELISA Kit for Related To Receptor Tyrosine Kinase (RYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM269Ra01 | Recombinant Related To Receptor Tyrosine Kinase (RYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM269Ra01 | Monoclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IP. |
| PAM269Ra01 | Polyclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM269Ra01 | CLIA Kit for Related To Receptor Tyrosine Kinase (RYK) | CLIA assay for Antigen Detection |
| ELM269Ra01 | ELISA Kit for Related To Receptor Tyrosine Kinase (RYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM269Ca01 | Recombinant Related To Receptor Tyrosine Kinase (RYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM269Ca01 | Monoclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IP. |
| PAM269Ca01 | Polyclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM269Ca01 | CLIA Kit for Related To Receptor Tyrosine Kinase (RYK) | CLIA assay for Antigen Detection |
| ELM269Ca01 | ELISA Kit for Related To Receptor Tyrosine Kinase (RYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM269Po01 | Recombinant Related To Receptor Tyrosine Kinase (RYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM269Po01 | Monoclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IP. |
| PAM269Po01 | Polyclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM269Po01 | CLIA Kit for Related To Receptor Tyrosine Kinase (RYK) | CLIA assay for Antigen Detection |
| ELM269Po01 | ELISA Kit for Related To Receptor Tyrosine Kinase (RYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM269Bo01 | Recombinant Related To Receptor Tyrosine Kinase (RYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM269Bo01 | Monoclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IP. |
| PAM269Bo01 | Polyclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM269Bo01 | CLIA Kit for Related To Receptor Tyrosine Kinase (RYK) | CLIA assay for Antigen Detection |
| ELM269Bo01 | ELISA Kit for Related To Receptor Tyrosine Kinase (RYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM269Rb01 | Recombinant Related To Receptor Tyrosine Kinase (RYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM269Rb01 | Monoclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IP. |
| PAM269Rb01 | Polyclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM269Rb01 | CLIA Kit for Related To Receptor Tyrosine Kinase (RYK) | CLIA assay for Antigen Detection |
| ELM269Rb01 | ELISA Kit for Related To Receptor Tyrosine Kinase (RYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPM269Mo01 | Recombinant Related To Receptor Tyrosine Kinase (RYK) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAM269Mo01 | Monoclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IP. |
| PAM269Mo01 | Polyclonal Antibody to Related To Receptor Tyrosine Kinase (RYK) | WB; IHC; ICC; IF. | |
| Assay Kits | CLM269Mo01 | CLIA Kit for Related To Receptor Tyrosine Kinase (RYK) | CLIA assay for Antigen Detection |
| ELM269Mo01 | ELISA Kit for Related To Receptor Tyrosine Kinase (RYK) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and chromosomal localisation of the human homologue of a receptor related to tyrosine kinases (RYK)."
Oncogene 8:1347-1356(1993) [PubMed] [Europe PMC] [Abstract]
"The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain."
Oncogene 8:2009-2014(1993) [PubMed] [Europe PMC] [Abstract]
"H-RYK, an unusual receptor kinase: isolation and analysis of expression in ovarian cancer."
Mol. Med. 2:189-203(1996) [PubMed] [Europe PMC] [Abstract]
"Functional analysis of H-Ryk, an atypical member of the receptor tyrosine kinase family."
Mol. Cell. Biol. 19:6427-6440(1999) [PubMed] [Europe PMC] [Abstract]
"Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth."
Cell 119:97-108(2004) [PubMed] [Europe PMC] [Abstract]
"Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract."
Nat. Neurosci. 8:1151-1159(2005) [PubMed] [Europe PMC] [Abstract]
"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]