RNA Exonuclease 2 Homolog (REXO2)

SFN; RFN; SMFN; Oligoribonuclease, mitochondrial; Small fragment nuclease

SPN	M264
HGNC	17851
MGI	1888981
PubMed	10851236
RGD	1304874
UniProt	Q9Y3B8
Wiki	REXO2

The deduced 205-amino acid protein has a calculated molecular mass of about 23.8 kD. The sequence shares about 50% identity with the E. coli Orn protein and contains 3 characteristic motifs, termed Exo I, II, and III, of the 3-prime-to-5-prime exonuclease superfamily. Four conserved negatively charged residues within the 3 Exo motifs are involved in positioning of the 2 divalent cations required for catalysis and phosphodiester bond cleavage. This variant appears to be a homolog of yeast Ynt20, which shows both RNAse and DNAse activity. Both SFN and SFN-alpha contain a consensus nuclear localization signal. Northern blot analysis revealed a 1-kb transcript expressed in all fetal and adult tissues tested, with highest levels in heart and relatively low levels in adult lymph nodes, brain, lung, liver, spleen, and thymus.

Reference

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"REXO2 is an oligoribonuclease active in human mitochondria."
PLoS ONE 8:E64670-E64670(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]