R-Spondin 1 (RSPO1)

RSPONDIN; Roof plate-specific spondin-1

SPN	M228
HGNC	21679
MGI	2183426
PubMed	21991325
RGD	1565558
UniProt	Q2MKA7
Wiki	RSPO1

RSPO1 is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.R-spondin transcripts were observed mainly in central nervous system (CNS) tissues, especially in association with the roof plate structure, in 10- and 12-dpc embryos. Outside the CNS, R-spondin transcripts were detected in forelimb buds after 10 dpc, especially in the body trunk and the proximal posterior part of the anterior limb bud. Expression was also observed in facial parenchyma surrounding the nasal cavity at 12 dpc.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM228Hu01	Recombinant R-Spondin 1 (RSPO1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM228Hu01	Monoclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IP.
Antibodies	PAM228Hu01	Polyclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IF.
Assay Kits	CLM228Hu01	CLIA Kit for R-Spondin 1 (RSPO1)	CLIA assay for Antigen Detection
Assay Kits	ELM228Hu01	ELISA Kit for R-Spondin 1 (RSPO1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM228Mu01	Recombinant R-Spondin 1 (RSPO1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM228Mu01	Monoclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IP.
Antibodies	PAM228Mu01	Polyclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IF.
Assay Kits	CLM228Mu01	CLIA Kit for R-Spondin 1 (RSPO1)	CLIA assay for Antigen Detection
Assay Kits	ELM228Mu01	ELISA Kit for R-Spondin 1 (RSPO1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM228Ra01	Recombinant R-Spondin 1 (RSPO1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM228Ra01	Monoclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IP.
Antibodies	PAM228Ra01	Polyclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IF.
Assay Kits	CLM228Ra01	CLIA Kit for R-Spondin 1 (RSPO1)	CLIA assay for Antigen Detection
Assay Kits	ELM228Ra01	ELISA Kit for R-Spondin 1 (RSPO1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM228Ca01	Recombinant R-Spondin 1 (RSPO1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM228Ca01	Monoclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IP.
Antibodies	PAM228Ca01	Polyclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IF.
Assay Kits	CLM228Ca01	CLIA Kit for R-Spondin 1 (RSPO1)	CLIA assay for Antigen Detection
Assay Kits	ELM228Ca01	ELISA Kit for R-Spondin 1 (RSPO1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM228Po01	Recombinant R-Spondin 1 (RSPO1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM228Po01	Monoclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IP.
Antibodies	PAM228Po01	Polyclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IF.
Assay Kits	CLM228Po01	CLIA Kit for R-Spondin 1 (RSPO1)	CLIA assay for Antigen Detection
Assay Kits	ELM228Po01	ELISA Kit for R-Spondin 1 (RSPO1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM228Bo01	Recombinant R-Spondin 1 (RSPO1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM228Bo01	Monoclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IP.
Antibodies	PAM228Bo01	Polyclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IF.
Assay Kits	CLM228Bo01	CLIA Kit for R-Spondin 1 (RSPO1)	CLIA assay for Antigen Detection
Assay Kits	ELM228Bo01	ELISA Kit for R-Spondin 1 (RSPO1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM228Rb01	Recombinant R-Spondin 1 (RSPO1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM228Rb01	Monoclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IP.
Antibodies	PAM228Rb01	Polyclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IF.
Assay Kits	CLM228Rb01	CLIA Kit for R-Spondin 1 (RSPO1)	CLIA assay for Antigen Detection
Assay Kits	ELM228Rb01	ELISA Kit for R-Spondin 1 (RSPO1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPM228Mo01	Recombinant R-Spondin 1 (RSPO1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAM228Mo01	Monoclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IP.
Antibodies	PAM228Mo01	Polyclonal Antibody to R-Spondin 1 (RSPO1)	WB; IHC; ICC; IF.
Assay Kits	CLM228Mo01	CLIA Kit for R-Spondin 1 (RSPO1)	CLIA assay for Antigen Detection
Assay Kits	ELM228Mo01	ELISA Kit for R-Spondin 1 (RSPO1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Mitogenic influence of human R-spondin1 on the intestinal epithelium."
Science 309:1256-1259(2005) [PubMed] [Europe PMC] [Abstract]

"R-spondin1 is essential in sex determination, skin differentiation and malignancy."
Nat. Genet. 38:1304-1309(2006) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."
Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract]

"LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."
EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]

"Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling."
Nature 476:293-297(2011) [PubMed] [Europe PMC] [Abstract]

"LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor."
PLoS ONE 7:E37137-E37137(2012) [PubMed] [Europe PMC] [Abstract]

"R-Spondin potentiates Wnt/beta-catenin signaling through orphan receptors LGR4 and LGR5."
PLoS ONE 7:E40976-E40976(2012) [PubMed] [Europe PMC] [Abstract]

"Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5."
Cell Rep. 3:1885-1892(2013) [PubMed] [Europe PMC] [Abstract]

"Structural basis for R-spondin recognition by LGR4/5/6 receptors."
Genes Dev. 27:1339-1344(2013) [PubMed] [Europe PMC] [Abstract]

"The structural basis of R-spondin recognition by LGR5 and RNF43."
Genes Dev. 27:1345-1350(2013) [PubMed] [Europe PMC] [Abstract]