R-Spondin 3 (RSPO3)

CRISTIN1; PWTSR; THSD2; Thrombospondin,Type I,Domain Containing 2; Protein with TSP type-1 repeat; Roof plate-specific spondin-3

SPN	M226
HGNC	20866
MGI	1920030
PubMed	22895193
RGD	1563246
UniProt	Q9BXY4
Wiki	RSPO3

RSPO3 encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.The 272-amino acid protein has an N-terminal cys-rich domain (CRD) and a central thrombospondin type-1 (THBS1) repeat (TSR) domain. Northern blot analysis detected 3.0- and 4.0-kb transcripts in placenta, lung, and skeletal muscle. RT-PCR revealed ubiquitous expression, with highest levels in placenta, small intestine, fetal thymus, and lymph node. RSPO3 expression was detected in all tumor tissues examined except a lung carcinoma and an ovarian carcinoma.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	M226Hu01	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	MM226Hu21	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	PM226Hu01	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	KEM226Hu	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant R-Spondin 3 (RSPO3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native R-Spondin 3 (RSPO3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to R-Spondin 3 (RSPO3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to R-Spondin 3 (RSPO3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for R-Spondin 3 (RSPO3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for R-Spondin 3 (RSPO3)	CLIA assay for Antigen Detection

Reference

"Cloning and identification of a cDNA that encodes a novel human protein with thrombospondin type I repeat domain, hPWTSR."
Mol. Biol. Rep. 29:287-292(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"R-spondin proteins: a novel link to beta-catenin activation."
Cell Cycle 5:23-26(2006) [PubMed] [Europe PMC] [Abstract]

"LGR4 and LGR5 are R-spondin receptors mediating Wnt/beta-catenin and Wnt/PCP signalling."
EMBO Rep. 12:1055-1061(2011) [PubMed] [Europe PMC] [Abstract]

"Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling."
Nature 476:293-297(2011) [PubMed] [Europe PMC] [Abstract]

"LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor."
PLoS ONE 7:E37137-E37137(2012) [PubMed] [Europe PMC] [Abstract]