Single Ig IL1 Related Receptor (SIGIRR)

TIR8; Single Ig IL-1R-related molecule; Toll/interleukin-1 receptor 8; Single immunoglobulin domain-containing IL1R-related protein

SPN	M170
HGNC	30575
MGI	1344402
PubMed	12925853
RGD	1306732
UniProt	Q6IA17
Wiki	SIGIRR

The deduced 410-amino acid human protein, which is 82% identical to the mouse sequence and 23% identical to IL1R, has no signal peptide and contains a short 118-amino acid single immunoglobulin (Ig) extracellular domain with 4 potential N-glycosylation sites; a transmembrane region; and a 268-amino acid cytoplasmic tail with 4 IL1R-like signaling motifs. However, 2 changes in the regions conserved with IL1R (ser447 in IL1R replaced by cys222 in motif 3 of SIGIRR, and tyr536 in IL1R replaced by leu305 in motif 4 of SIGIRR) are predicted to abrogate signaling capabilities. Northern blot analysis revealed wide but differential expression of predominant 2.4- and 1.5-kb transcripts and minor 4.4- and 0.9-kb transcripts in all tissues tested.

Reference

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily."
Cytokine 11:389-399(1999) [PubMed] [Europe PMC] [Abstract]

"Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR."
Eur. Cytokine Netw. 14:211-218(2003) [PubMed] [Europe PMC] [Abstract]

"SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling."
Nat. Immunol. 4:920-927(2003) [PubMed] [Europe PMC] [Abstract]

"SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms."
J. Biol. Chem. 280:25233-25241(2005) [PubMed] [Europe PMC] [Abstract]

"Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation."
Clin. Exp. Immunol. 162:348-361(2010) [PubMed] [Europe PMC] [Abstract]

"A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3."
Biochem. Biophys. Res. Commun. 404:1029-1033(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]