CD27 Binding Protein (CD27BP)

SIVA; SIVA1,Apoptosis-Inducing Factor; Apoptosis regulatory protein Siva

SPN	M166
HGNC	17712
MGI	1353606
PubMed	19643733
RGD	1561872
UniProt	O15304
Wiki	19643733

CD27BP encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.Sequence analysis predicted that the 189-amino acid protein has an N-terminal ring finger and a cys-rich C terminus containing death domains with homology to those in FADD and RIP, as well as motifs that may form a B box-like ring finger, although it lacks his residues and coiled-coil domain structures. Northern blot analysis revealed ubiquitous expression of a 0.8-kb transcript that was greatest in thymus and lowest in colon.

Reference

"CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein."
Proc. Natl. Acad. Sci. U.S.A. 94:6346-6351(1997) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva."
J. Virol. 74:4284-4290(2000) [PubMed] [Europe PMC] [Abstract]

"The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress."
J. Biol. Chem. 276:11465-11468(2001) [PubMed] [Europe PMC] [Abstract]

"The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva."
Virology 289:15-22(2001) [PubMed] [Europe PMC] [Abstract]

"Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis."
Proc. Natl. Acad. Sci. U.S.A. 99:6925-6930(2002) [PubMed] [Europe PMC] [Abstract]

"The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis."
Apoptosis 9:83-95(2004) [PubMed] [Europe PMC] [Abstract]

"Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway."
J. Immunol. 172:4008-4017(2004) [PubMed] [Europe PMC] [Abstract]

"Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2."
Cancer Res. 65:5301-5309(2005) [PubMed] [Europe PMC] [Abstract]

"The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22."
Mol. Cell. Biochem. 287:147-155(2006) [PubMed] [Europe PMC] [Abstract]

"Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD)."
Oncogene 25:3458-3462(2006) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]