Secreted Ly6/uPAR Related Protein 1 (SLURP1)

ARS; ANUP; ArsB; LY6LS; MDM; Lymphocyte Antigen 6-Like Secreted; ARS Component B; Anti-neoplastic urinary protein

SPN	M159
HGNC	18746
MGI	1930923
PubMed	23139280
RGD	1308768
UniProt	P55000
Wiki	SLURP1

SLURP1 is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors.

The Ly6/uPAR protein family can be divided into 2 subfamilies. One comprises glycosylphosphatidylinositol (GPI)-anchored glycoprotein receptors with 10 cysteine residues. The other subfamily includes the secreted single-domain snake and frog cytotoxins, and its members generally possess only 8 cysteines and no GPI-anchoring signal sequence.

Reference

"Biological effects of SLURP-1 on human keratinocytes."
J. Invest. Dermatol. 125:1236-1241(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumour effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes."
Cytokine 8:1-5(1996) [PubMed] [Europe PMC] [Abstract]

"Structural and phylogenetic characterization of human SLURP-1, the first secreted mammalian member of the Ly-6/uPAR protein superfamily."
Protein Sci. 8:810-819(1999) [PubMed] [Europe PMC] [Abstract]

"ARS component B: structural characterization, tissue expression and regulation of the gene and protein (SLURP-1) associated with Mal de Meleda."
Eur. J. Dermatol. 13:560-570(2003) [PubMed] [Europe PMC] [Abstract]

"SLURP1 is a late marker of epidermal differentiation and is absent in Mal de Meleda."
J. Invest. Dermatol. 127:301-308(2007) [PubMed] [Europe PMC] [Abstract]

"Mutations in the gene encoding SLURP-1 in Mal de Meleda."
Hum. Mol. Genet. 10:875-880(2001) [PubMed] [Europe PMC] [Abstract]

"Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates."
Hum. Genet. 112:50-56(2003) [PubMed] [Europe PMC] [Abstract]

"Heterozygous manifestations in female carriers of Mal de Meleda."
Clin. Genet. 65:244-246(2004) [PubMed] [Europe PMC] [Abstract]