Tomoregulin (TR)
TMEFF2; TENB2; HPP1; TPEF; CT120.2; Transmembrane Protein With EGF-Like And Two Follistatin-Like Domains 2; Hyperplastic polyposis protein 1
The deduced 368-amino acid TRa protein contains 2 follistatin-like domains and a conserved EGF-like domain. It also has a predicted N-terminal signal peptide, a transmembrane domain, a cytosolic tail G protein-activating motif, and potential sites for N-linked glycosylation and glycosaminoglycan attachment. Unlike other EGF/NRG family members, TRa has a histidine replacing a conserved arginine essential for EGF receptor recognition. The TRb and TRc proteins contain 418 and 379 amino acids, respectively, and differ from one another and TRa in the cytoplasmic domain. Northern blot analysis detected expression of approximately 2.2- and 3.1-kb TR transcripts predominantly in brain. The 374-amino acid TMEFF2 protein shares approximately 36% and 99% sequence identity with TMEFF1 and mouse Tmeff2, respectively.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | M019Hu01 | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| PM019Hu01 | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | NONE | Recombinant Tomoregulin (TR) | Positive Control; Immunogen; SDS-PAGE; WB. |
| NONE | Native Tomoregulin (TR) | Bioactivity | |
| Antibodies | NONE | Monoclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IP. |
| NONE | Polyclonal Antibody to Tomoregulin (TR) | WB; IHC; ICC; IF. | |
| NONE | Biotin Linked-Polyclonal Antibody to Tomoregulin (TR) | ELISA(Det);IC; IH; IH(P); WB | |
| NONE | APC Linked-Polyclonal Antibody to Tomoregulin (TR) | IHC, WB | |
| NONE | HRP Linked-Polyclonal Antibody to Tomoregulin (TR) | Simple Western; WB | |
| NONE | PE Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry | |
| NONE | FITC Linked-Polyclonal Antibody to Tomoregulin (TR) | Flow Cytometry;ICC/IF | |
| Assay Kits | NONE | ELISA Kit for Tomoregulin (TR) | Enzyme-linked immunosorbent assay for Antigen Detection |
| NONE | CLIA kit for Tomoregulin (TR) | CLIA assay for Antigen Detection |
Reference
"Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons."
Genomics 67:146-152(2000) [PubMed] [Europe PMC] [Abstract]
"The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells."
Cancer Res. 60:4907-4912(2000) [PubMed] [Europe PMC] [Abstract]
"TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence."
Int. J. Cancer 94:178-184(2001) [PubMed] [Europe PMC] [Abstract]
"A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells."
Genomics 87:633-637(2006) [PubMed] [Europe PMC] [Abstract]
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells."
Biochem. Biophys. Res. Commun. 266:593-602(1999) [PubMed] [Europe PMC] [Abstract]
"HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers."
Proc. Natl. Acad. Sci. U.S.A. 98:265-270(2001) [PubMed] [Europe PMC] [Abstract]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
"Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain."
J. Neurochem. 98:34-44(2006) [PubMed] [Europe PMC] [Abstract]
"Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17."
J. Biol. Chem. 282:37378-37388(2007) [PubMed] [Europe PMC] [Abstract]
"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]