TNFRSF1A Associated Via Death Domain Protein (TRADD)

Tumor Necrosis Factor Receptor Type 1-Associated DEATH Domain Protein; TNFRSF1A-associated via death domain

SPN	M007
HGNC	12030
MGI	109200
PubMed	7758105
RGD	621313
UniProt	Q15628
Wiki	TRADD

TRADD is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. TRADD contains a 111-amino acid death domain with sequence similarity to that of TNFR1. The 1.4-kb TRADD mRNA is expressed ubiquitously.TRADD-mediated cell death could be suppressed by expression of the cowpox virus crmA gene, which encodes an inhibitor of ICE, a cysteine protease involved in TNF-induced apoptosis.

Reference

"The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation."
Cell 81:495-504(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex."
Immunity 4:387-396(1996) [PubMed] [Europe PMC] [Abstract]

"The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation."
EMBO J. 18:3044-3053(1999) [PubMed] [Europe PMC] [Abstract]

"The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells."
Biochem. Biophys. Res. Commun. 277:513-517(2000) [PubMed] [Europe PMC] [Abstract]

"Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD."
J. Cell Biol. 155:415-426(2001) [PubMed] [Europe PMC] [Abstract]

"AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation."
J. Biol. Chem. 279:44955-44965(2004) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway."
Mol. Cell 5:1051-1057(2000) [PubMed] [Europe PMC] [Abstract]

"A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction."
Cell 101:777-787(2000) [PubMed] [Europe PMC] [Abstract]