Fibroblast Growth Factor 15 (FGF15)

SPN	L949
MGI	1096383
PubMed	15081372
RGD	620166
UniProt	O35622
Wiki	FGF15

FGF15 is the mouse ortholog of human FGF19 (hence there is no human FGF15).

Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin-binding proteins and interactions with cell-surface associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues.

Fibroblast growth factor was found in pituitary extracts by Armelin in 1973 and then was also found in a cow brain extract by Gospodarowicz et al. and tested in a bioassay which caused fibroblasts to proliferate (first published report in 1974).

Reference

"A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1."
Development 124:3221-3232(1997) [PubMed] [Europe PMC] [Abstract]

"The transcriptional landscape of the mammalian genome."
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis."
Cell Metab. 2:217-225(2005) [PubMed] [Europe PMC] [Abstract]