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Pentraxin 3, Long (PTX3)

TNFAIP5; TSG-14; Pentaxin-Related Gene,Rapidly Induced By IL-1 Beta; Tumor Necrosis Factor Alpha-Induced Protein 5; Tumor necrosis factor-inducible gene 14 protein

PTX3 bound selected pathogens, including Aspergillus fumigatus, Pseudomonas aeruginosa, and Salmonella typhimurium. PTX3 bound to either viable or heat-inactivated conidia, but not the hyphae, of A. fumigatus, and Ptx3 facilitated conidia interaction with mononuclear phagocytes. Conidia rapidly induced PTX3 production in human and mouse monocytes and dendritic cells, but not in neutrophils, fibroblasts, or endothelial or epithelial cells. Infection of mice and humans with A. fumigatus induced high levels of PTX3 in plasma and bronchoalveolar lavage fluid. Significant levels of PTX3 were detected in plasma of neutropenic patients with systemic A. fumigatus infection, but only low levels were found in control subjects.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL918Hu01 Recombinant Pentraxin 3, Long (PTX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL918Hu01 Monoclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IP.
PAL918Hu01 Polyclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IF.
Assay Kits CLL918Hu01 CLIA Kit for Pentraxin 3, Long (PTX3) CLIA assay for Antigen Detection
ELL918Hu01 ELISA Kit for Pentraxin 3, Long (PTX3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL918Mu01 Recombinant Pentraxin 3, Long (PTX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL918Mu01 Monoclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IP.
PAL918Mu01 Polyclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IF.
Assay Kits CLL918Mu01 CLIA Kit for Pentraxin 3, Long (PTX3) CLIA assay for Antigen Detection
ELL918Mu01 ELISA Kit for Pentraxin 3, Long (PTX3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL918Ra01 Recombinant Pentraxin 3, Long (PTX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL918Ra01 Monoclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IP.
PAL918Ra01 Polyclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IF.
Assay Kits CLL918Ra01 CLIA Kit for Pentraxin 3, Long (PTX3) CLIA assay for Antigen Detection
ELL918Ra01 ELISA Kit for Pentraxin 3, Long (PTX3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL918Ca01 Recombinant Pentraxin 3, Long (PTX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL918Ca01 Monoclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IP.
PAL918Ca01 Polyclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IF.
Assay Kits CLL918Ca01 CLIA Kit for Pentraxin 3, Long (PTX3) CLIA assay for Antigen Detection
ELL918Ca01 ELISA Kit for Pentraxin 3, Long (PTX3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL918Po01 Recombinant Pentraxin 3, Long (PTX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL918Po01 Monoclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IP.
PAL918Po01 Polyclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IF.
Assay Kits CLL918Po01 CLIA Kit for Pentraxin 3, Long (PTX3) CLIA assay for Antigen Detection
ELL918Po01 ELISA Kit for Pentraxin 3, Long (PTX3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL918Bo01 Recombinant Pentraxin 3, Long (PTX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL918Bo01 Monoclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IP.
PAL918Bo01 Polyclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IF.
Assay Kits CLL918Bo01 CLIA Kit for Pentraxin 3, Long (PTX3) CLIA assay for Antigen Detection
ELL918Bo01 ELISA Kit for Pentraxin 3, Long (PTX3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL918Rb01 Recombinant Pentraxin 3, Long (PTX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL918Rb01 Monoclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IP.
PAL918Rb01 Polyclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IF.
Assay Kits CLL918Rb01 CLIA Kit for Pentraxin 3, Long (PTX3) CLIA assay for Antigen Detection
ELL918Rb01 ELISA Kit for Pentraxin 3, Long (PTX3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL918Mo01 Recombinant Pentraxin 3, Long (PTX3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL918Mo01 Monoclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IP.
PAL918Mo01 Polyclonal Antibody to Pentraxin 3, Long (PTX3) WB; IHC; ICC; IF.
Assay Kits CLL918Mo01 CLIA Kit for Pentraxin 3, Long (PTX3) CLIA assay for Antigen Detection
ELL918Mo01 ELISA Kit for Pentraxin 3, Long (PTX3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component."
J. Biol. Chem. 267:22190-22197(1992) [PubMed] [Europe PMC] [Abstract]

"IL-1 inducible genes in human umbilical vein endothelial cells."
Eur. Heart J. 14:78-81(1993) [PubMed] [Europe PMC] [Abstract]

"TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins."
J. Immunol. 150:1804-1812(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins."
J. Immunol. 153:3700-3707(1994) [PubMed] [Europe PMC] [Abstract]

"Pentraxin 3, a non-redundant soluble pattern recognition receptor involved in innate immunity."
Vaccine 21:S43-S47(2003) [PubMed] [Europe PMC] [Abstract]

"Structural characterization of PTX3 disulfide bond network and its multimeric status in cumulus matrix organization."
J. Biol. Chem. 283:10147-10161(2008) [PubMed] [Europe PMC] [Abstract]