Dicer 1, Ribonuclease Type III (DICER1)

Dicer; HERNA; Dicer 1,Double-Stranded RNA-Specific Endoribonuclease; Helicase with RNase motif; Helicase MOI

SPN	L881
HGNC	17098
MGI	2177178
PubMed	21266384
RGD	1309381
UniProt	Q9UPY3
Wiki	DICER1

DICER1 encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene.A 2.1-kb clone contained a partial cDNA of a human protein with high homology to the hypothetical helicase K12H4.8 from C. elegans. Analysis of the predicted amino acid sequence revealed the presence of an RNase III motif and a double-stranded RNA (dsRNA)-binding domain, indicative of a protein of nuclear origin. C. elegans K12H4.8 and the human homolog share 58% identity over 275 amino acids.

Reference

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Cell 118:57-68(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer."
EMBO Rep. 5:189-194(2004) [PubMed] [Europe PMC] [Abstract]

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Cell 123:631-640(2005) [PubMed] [Europe PMC] [Abstract]

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Nature 436:740-744(2005) [PubMed] [Europe PMC] [Abstract]

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"Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA."
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"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function."
Nat. Genet. 41:365-370(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Extending the phenotypes associated with DICER1 mutations."
Hum. Mutat. 32:1381-1384(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Human RNA methyltransferase BCDIN3D regulates microRNA processing."
Cell 151:278-288(2012) [PubMed] [Europe PMC] [Abstract]

"Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Homodimeric structure and double-stranded RNA cleavage activity of the C-terminal RNase III domain of human dicer."
J. Mol. Biol. 374:106-120(2007) [PubMed] [Europe PMC] [Abstract]

"DICER1 mutations in familial pleuropulmonary blastoma."
Science 325:965-965(2009) [PubMed] [Europe PMC] [Abstract]

"DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors."
JAMA 305:68-77(2011) [PubMed] [Europe PMC] [Abstract]