Tsukushin (TSK)

E2IG4; TSKU; LRRC54; Tsukushi; E2-induced gene 4 protein; Leucine Rich Repeat Containing 54; Tsukushi Small Leucine Rich Proteoglycan Homolog

SPN	L800
HGNC	28850
MGI	2443855
PubMed	11085516
RGD	1359311
UniProt	Q8WUA8

Tsk is a BMP inhibitor in oviparous vertebrates that forms a ternary complex with Bmp and chordin and is involved in the regulation of primitive streak and Hensen node.

Using transcript-specific PCR primers for novel sequences that increased more than 10-fold upon treatment with 17-beta estradiol (E2), they cloned 5 cDNAs, designated E2-induced genes (E2IG) 1-5, from a human placenta cDNA library. The E2IG4 cDNA encodes a deduced 353-amino acid protein containing a leucine-rich repeat in the N terminus and 8 additional leucine-rich repeats. E2IG4 demonstrates domain and structural homology to extracellular matrix leucine-rich proteoglycans such as decorin and biglycan . It also contains various potential phosphorylation sites.

Reference

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BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]