Lin-28 Homolog A (LIN28A)

ZCCHC1; CSDD1; LIN28; Zinc finger CCHC domain-containing protein 1

SPN	L682
HGNC	15986
MGI	1890546
PubMed	20512147
RGD	1566408
UniProt	Q9H9Z2
Wiki	LIN28

LIN28 protein is stage-specifically expressed in embryonic muscle, neurons, and epithelia, as well as in embryonic carcinoma cells; however, it is suppressed in most adult tissues except for skeletal and cardiac muscle.LIN28 mRNA is a target of the micro RNAs miR-125b and miRNA-125a.When the miREs were deleted, miRNA control over LIN28 nearly vanished. Lin28 downregulation by miR-125 involved reductions in both translational efficiency and mRNA abundance.An important target of Lin28 is Igf2, a growth and differentiation factor for muscle tissue. Interaction of Lin28 with translation initiation complexes in skeletal myoblasts and in the embryonic carcinoma cell line P19 was confirmed by localization of Lin28 to the stress granules, temporary structures that contain stalled mRNA-protein translation complexes.

Reference

"Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites."
Dev. Biol. 258:432-442(2003) [PubMed] [Europe PMC] [Abstract]

Erratum
Dev. Biol. 262:361-361(2003)

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation."
Genome Biol. 5:R13.1-R13.11(2004) [PubMed] [Europe PMC] [Abstract]

"The transcriptome profile of human embryonic stem cells as defined by SAGE."
Stem Cells 22:51-64(2004) [PubMed] [Europe PMC] [Abstract]

"Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells."
Dev. Dyn. 232:487-497(2005) [PubMed] [Europe PMC] [Abstract]

"Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down-regulation of putative targets during differentiation."
J. Biol. Chem. 280:16635-16641(2005) [PubMed] [Europe PMC] [Abstract]

"Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells."
Mol. Cell. Biol. 25:9198-9208(2005) [PubMed] [Europe PMC] [Abstract]

"Localization of the developmental timing regulator Lin28 to mRNP complexes, P-bodies and stress granules."
RNA Biol. 4:16-25(2007) [PubMed] [Europe PMC] [Abstract]

"Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA."
Mol. Cell 32:276-284(2008) [PubMed] [Europe PMC] [Abstract]

"TUT4 in concert with Lin28 suppresses MicroRNA biogenesis through pre-microRNA uridylation."
Cell 138:696-708(2009) [PubMed] [Europe PMC] [Abstract]

"Lin28 promotes transformation and is associated with advanced human malignancies."
Nat. Genet. 41:843-848(2009) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the zinc-finger domain in LIN-28."
Submitted (NOV-2005) to the PDB data bank

"Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28."
Nat. Struct. Mol. Biol. 19:84-89(2012) [PubMed] [Europe PMC] [Abstract]