Keratin 71 (KRT71)

KRT6IRS; KRT6IRS1; K6IRS1; CK-71; K71; Cytokeratin-71; Type II inner root sheath-specific keratin-K6irs1; Type-II keratin Kb34; Keratin, type II cytoskeletal 71

SPN	L315
HGNC	28927
MGI	1861586
PubMed	22592156
UniProt	Q3SY84
Wiki	KRT71

KRT71 belongs to a family of type II keratins that are specifically expressed in the inner root sheath of hair follicles. The deduced 523-amino acid protein has a calculated molecular mass of 57.3 kD. K6IRS1 has a central alpha-helical rod domain and shares approximately 92% amino acid identity with mouse K6irs1. In situ hybridization and indirect immunofluorescence of human hair follicles demonstrated K6IRS1 expression in the Henle and Huxley layers and in the cuticle of the inner root sheath. In all 3 layers, expression of K6IRS1 began above the germinative cell pool and terminated higher up in the follicle with the asynchronous terminal differentiation of each cell layer. K6IRS1 was also detected in the pseudopods of specialized Huxley cells, termed 'Flugelzellen,' which means 'winged cells.'

Reference

"A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flugelzellen) of the human hair follicle."
J. Invest. Dermatol. 118:789-799(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle."
J. Invest. Dermatol. 120:512-522(2003) [PubMed] [Europe PMC] [Abstract]

"K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle."
J. Invest. Dermatol. 126:2377-2386(2006) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"A missense mutation within the helix initiation motif of the keratin K71 gene underlies autosomal dominant woolly hair/hypotrichosis."
J. Invest. Dermatol. 132:2342-2349(2012) [PubMed] [Europe PMC] [Abstract]