Chemokine Like Factor Superfamily 8 (CKLFSF8)

CMTM8; CKLF-Like MARVEL Transmembrane Domain Containing 8; CKLF-like MARVEL transmembrane domain-containing protein 8

SPN	L302
HGNC	19179
MGI	2447167
RGD	735040
UniProt	Q8IZV2

Members of the chemokine-like factor superfamily, including CKLFSF8, share similarity with both the chemokine and the transmembrane 4 superfamilies of signaling molecules.

By screening databases for sequences that share homology with chemokine-like factor (CKLF), followed by RT-PCR of a tonsil cDNA library, Han et al. (2003) cloned CKLFSF8. The deduced 173-amino acid protein has 4 transmembrane segments and shares about 39% sequence identity with TM4SF11. Northern blot analysis detected a 1.18-kb transcript expressed at high levels in liver and pancreas. Han et al. (2003) also cloned mouse Cklfsf8, which shares more than 95% sequence similarity with CKLFSF8.

Reference

"Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation."
Genomics 81:609-617(2003) [PubMed] [Europe PMC] [Abstract]

"An alternative splice form of CMTM8 induces apoptosis."
Int. J. Biochem. Cell Biol. 39:2107-2119(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]