Osterix (OSX)

Sp7 Transcription Factor; Specificity Protein 7; Zinc finger protein osterix

SPN	L092
HGNC	17321
MGI	2159409
PubMed	16041384
RGD	631377
UniProt	Q8TDD2

Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. OSX is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.The deduced 431-amino acid protein has a calculated molecular mass of 45 kD and contains an N-terminal proline-rich domain and 3 consecutive C-terminal C2H2 zinc finger motifs. Mouse and human SP7 share 95% amino acid identity. The lack of a glutamine-rich domain and the presence of a proline-rich domain distinguish SP7 from other SP family proteins. In situ hybridization of human embryonic tissues revealed SP7 expression in osteoblastic cells of the appendicular and craniofacial skeleton.

Reference

"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation."
Cell 108:17-29(2002) [PubMed] [Europe PMC] [Abstract]

"Expression of alternatively spliced isoforms of human Sp7 in osteoblast-like cells."
BMC Genomics 4:43-43(2003) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning, structure, expression, and chromosomal localization of the human Osterix (SP7) gene."
Gene 341:101-110(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of a frameshift mutation in Osterix in a patient with recessive osteogenesis imperfecta."
Am. J. Hum. Genet. 87:110-114(2010) [PubMed] [Europe PMC] [Abstract]

"Characterization of Osterix protein stability and physiological role in osteoblast differentiation."
PLoS ONE 8:E56451-E56451(2013) [PubMed] [Europe PMC] [Abstract]