Carbon Catabolite Repression 4 Like Protein (CCRN4L)

CCR4L; CCR4; NOC; Nocturnin; Circadian deadenylase NOC; Carbon catabolite repression 4-like protein

SPN	K766
HGNC	14254
MGI	109382
PubMed	24821610
RGD	1587344
UniProt	Q9UK39

CCRN4L is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.

The deduced protein contains 439 amino acids. Mouse and human CCRN4L share 93% amino acid similarity, and both contain a conserved motif involved in Mg(2+) and Mn(2+) binding among apurinic-apyrimidinic endonuclease family I members, as well as several phosphorylation and glycosylation sites.

Reference

"Characterization of a mammalian gene related to the yeast CCR4 general transcription factor and revealed by transposon insertion."
J. Biol. Chem. 274:31068-31075(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The role of nocturnin in early adipogenesis and modulation of systemic insulin resistance in human."
Obesity 20:1558-1565(2012) [PubMed] [Europe PMC] [Abstract]

"Nocturnin: at the crossroads of clocks and metabolism."
Trends Endocrinol. Metab. 23:326-333(2012) [PubMed] [Europe PMC] [Abstract]