C-Type Lectin Domain Family 11, Member A (CLEC11A)

SCGF; P47; LSLCL; CLECSF3; Stem Cell Growth Factor; Lymphocyte Secreted C-Type Lectin; C-type lectin superfamily member 3

SPN	K383
HGNC	10576
MGI	1298219
PubMed	9207134
RGD	3627
UniProt	Q9Y240
Wiki	CLEC11A

CLEC11A encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. Sequence analysis revealed a 21-amino acid signal peptide; a glutamate-rich N-terminal domain, which includes an arg-gly-asp triplet; a leucine zipper; and a C-terminal C-type lectin domain, which is known to be a carbohydrate recognition domain. The authors found O-glycan attachment sites but no N-glycosylation sites. Northern blot analysis detected a 1.4-kb transcript that was strongly expressed in T and B lymphoblastoid, weakly expressed in monocytoid cell lines, and not expressed in fibroblasts.

Reference

"Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells."
J. Biol. Chem. 273:1911-1916(1998) [PubMed] [Europe PMC] [Abstract]

Ref.1"Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells."
J. Biol. Chem. 273:1911-1916(1998) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of a cDNA for human, mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily."
Biochem. Biophys. Res. Commun. 249:124-130(1998) [PubMed] [Europe PMC] [Abstract]

Ref.2"Isolation and characterization of a cDNA for human, mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily."
Biochem. Biophys. Res. Commun. 249:124-130(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: a new model of exon shuffling."
Genomics 57:316-317(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

Ref.6"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells."
Hematol. J. 2:307-315(2001) [PubMed] [Europe PMC] [Abstract]

"Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils."
C. R. Acad. Sci. III, Sci. Vie 324:1125-1132(2001) [PubMed] [Europe PMC] [Abstract]