RAB5C, Member RAS Oncogene Family (RAB5C)

RABL; RAB5CL; Ras-related protein Rab-5C

SPN	K296
HGNC	9785
MGI	105306
PubMed	22734003
RGD	1307095
UniProt	P51148
Wiki	RAB5C

Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment. Han et al. (1996) isolated fetal lung cDNAs encoding a RAB protein that they designated RABL (RAB5-like). The predicted 216-amino acid RABL protein shares 86% identity with RAB5A and RAB5B and contains the conserved GTP-binding site characteristic of RAS proteins. RT-PCR analysis revealed that RABL is expressed ubiquitously. By analysis of cloned segments, Albertsen et al. (1994) determined that the RABL gene, which they called BC1-16, is located in the BRCA1 gene region on chromosome 17q12-q21. Han et al. (1996) refined the map position to 17q21.2 using FISH.

Reference

"Isolation and mapping of a human gene (RABL) encoding a small GTP-binding protein homologous to the Ras-related RAB gene."
Cytogenet. Cell Genet. 73:137-139(1996) [PubMed] [Europe PMC] [Abstract]

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"Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate."
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"Determinants of Rab5 interaction with the N-terminus of early endosome antigen 1."
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