Laminin Receptor 1 (LAMR1)

RPSA; LRP; 37LRP; p40; 40S ribosomal protein SA; 37 kDa laminin receptor precursor; Colon carcinoma laminin-binding protein; Multidrug resistance-associated protein MGr1-Ag

SPN	K175
HGNC	6502
MGI	105381
PubMed	14730304
RGD	71026
UniProt	P08865

LAMR1 has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as the fibronectin and vitronectin receptors. Incorporation of the laminin receptor into lysosomal membranes made it possible for lysosomes to attach to surfaces coated with laminin.The particular patterns were accounted for by the presence of up to 16 and 21 copies of the laminin receptor gene per haploid genome in human and mouse, respectively. Pseudogenes were identified on chromosomes 3, 12, 14, and X. The features suggested that the laminin receptor gene belongs to a retroposon family in mammals.The deduced 295-amino acid protein has a highly negatively charged C-terminal segment and lacks consensus sequences for an N-terminal signal sequence, amphipathic alpha-helices, and N-glycosylation sites.

Reference

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"Characteristics of a multicopy gene family predominantly consisting of processed pseudogenes."
Nucleic Acids Res. 17:3829-3843(1989) [PubMed] [Europe PMC] [Abstract]

"Cloning of 67-kDa laminin receptor cDNA and gene expression in normal and malignant cell lines of the human lung."
Cancer Lett. 62:199-203(1992) [PubMed] [Europe PMC] [Abstract]

"Isolation from a multigene family of the active human gene of the metastasis-associated multifunctional protein 37LRP/p40 at chromosome 3p21.3."
Oncogene 13:495-503(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (JUL-2004) to UniProtKB

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"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"The gene for human E2 small nucleolar RNA resides in an intron of a laminin-binding protein gene."
Genomics 30:400-401(1995) [PubMed] [Europe PMC] [Abstract]

"Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin."
Proc. Natl. Acad. Sci. U.S.A. 83:7137-7141(1986) [PubMed] [Europe PMC] [Abstract]

"A map of 75 human ribosomal protein genes."
Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract]

"Laminin receptor on human breast carcinoma cells."
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"Functional domains of the 67-kDa laminin receptor precursor."
J. Biol. Chem. 266:20440-20446(1991) [PubMed] [Europe PMC] [Abstract]

"Interaction between the 67 kilodalton metastasis-associated laminin receptor and laminin."
Kidney Int. 43:30-37(1993) [PubMed] [Europe PMC] [Abstract]

"The human 37-kDa laminin receptor precursor interacts with the prion protein in eukaryotic cells."
Nat. Med. 3:1383-1388(1997) [PubMed] [Europe PMC] [Abstract]

"Formation of the 67-kDa laminin receptor by acylation of the precursor."
J. Cell. Biochem. 69:244-251(1998) [PubMed] [Europe PMC] [Abstract]

"The 67-kDa laminin receptor originated from a ribosomal protein that acquired a dual function during evolution."
Mol. Biol. Evol. 15:1017-1025(1998) [PubMed] [Europe PMC] [Abstract]

"Ribosome-associated protein LBP/p40 binds to S21 protein of 40S ribosome: analysis using a yeast two-hybrid system."
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"Phage display mapping for peptide 11 sensitive sequences binding to laminin-1."
J. Mol. Biol. 298:431-445(2000) [PubMed] [Europe PMC] [Abstract]

"The 37-kDa/67-kDa laminin receptor acts as the cell-surface receptor for the cellular prion protein."
EMBO J. 20:5863-5875(2001) [PubMed] [Europe PMC] [Abstract]

"The protein phosphatase-1 targeting subunit TIMAP regulates LAMR1 phosphorylation."
Biochem. Biophys. Res. Commun. 338:1327-1334(2005) [PubMed] [Europe PMC] [Abstract]

"67-kDa laminin receptor promotes internalization of cytotoxic necrotizing factor 1-expressing Escherichia coli K1 into human brain microvascular endothelial cells."
J. Biol. Chem. 280:1360-1368(2005) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
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"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the human laminin receptor precursor."
J. Biol. Chem. 283:3002-3005(2008) [PubMed] [Europe PMC] [Abstract]