Histone Cluster 1, H4a (HIST1H4A)

H4FA; HIST2H4B; HIST2H4C; HIST2H4D; HIST2H4E; HIST2H4F; HIST2H4G; HIST2H4H; HIST2H4I; HIST2H4J; HIST2H4K; HIST2H4B; HIST4H4; HIST2H4A

SPN	K076
HGNC	4781
MGI	2448419
PubMed	9119399
RGD	620814
UniProt	P62805
Wiki	HIST1H4A

Acetylation of histone H4 on lysine-16 (H4-K16Ac) is a prevalent and reversible posttranslational chromatin modification in eukaryotes. Shogren-Knaak et al. (2006) used a native chemical ligation strategy to generate histone H4 that was homogeneously acetylated at K16. The incorporation of this modified histone into nucleosomal arrays inhibited the formation of compact 30-nanometer-like fibers and impeded the ability of chromatin to form cross-fiber interactions. H4-K16Ac also inhibited the ability of the adenosine triphosphate-utilizing chromatin assembly and remodeling enzyme ACF to mobilize a mononucleosome, indicating that this single histone modification modulates both higher order chromatin structure and functional interactions between a nonhistone protein and the chromatin fiber.

Reference

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