Fatty Acid Amide Hydrolase (FAAH)

FAAH-1; Anandamide amidohydrolase 1; Oleamide hydrolase 1

SPN	K024
HGNC	3553
MGI	109609
PubMed	20029375
RGD	61808
UniProt	O00519
Wiki	FAAH

Genes from all 3 organisms encode predicted 579-amino acid proteins that each contain a putative transmembrane domain, an amidase consensus sequence, and a putative SH3-binding motif. The sequence of the human protein is 82% and 84% identical to those of rat and mouse FAAH, respectively. Mammalian cells expressing rat or human FAAH exhibited high levels of oleamide hydrolase activity. Western blotting and cell fractionation studies indicated that this activity was associated with a 60 to 65 kD membrane protein. Human and rat FAAHs hydrolyzed a similar variety of fatty acid amides, although the human enzyme was quantitatively somewhat less selective. Northern blot analysis revealed that human FAAH is expressed as a 2.1-kb mRNA in various tissues, but not in heart or lung.

Reference

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Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

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Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

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"A missense mutation in human fatty acid amide hydrolase associated with problem drug use."
Proc. Natl. Acad. Sci. U.S.A. 99:8394-8399(2002) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

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Hum. Mol. Genet. 13:2113-2119(2004) [PubMed] [Europe PMC] [Abstract]

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Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"Association of a functional FAAH polymorphism with methamphetamine-induced symptoms and dependence in a Malaysian population."
Pharmacogenomics 14:505-514(2013) [PubMed] [Europe PMC] [Abstract]