BMX Non Receptor Tyrosine Kinase (BMX)

ETK; PSCTK3; NTK38; Epithelial and endothelial tyrosine kinase; Bone marrow tyrosine kinase gene in chromosome X; Cytoplasmic tyrosine-protein kinase BMX

SPN	J877
HGNC	1079
MGI	1101778
PubMed	7970727
RGD	1565643
UniProt	P51813
Wiki	BMX

BMX encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.BMX is transcribed in bone marrow as well as endothelial cells, and by Western blot analysis they detected an 80-kD protein corresponding to BMX in human endothelial cells. A similar size protein was identified in COS cells transfected with a BMX expression vector.

Reference

"BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2."
Oncogene 9:3683-3688(1994) [PubMed] [Europe PMC] [Abstract]

"Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells."
Proc. Natl. Acad. Sci. U.S.A. 95:3644-3649(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases."
Biochim. Biophys. Acta 1645:123-132(2003) [PubMed] [Europe PMC] [Abstract]

Thesis (1994), Cornell University, United States

"Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation."
Mol. Cell. Biol. 20:2043-2054(2000) [PubMed] [Europe PMC] [Abstract]

"Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain."
Nat. Cell Biol. 3:439-444(2001) [PubMed] [Europe PMC] [Abstract]

"Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
J. Biol. Chem. 277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]

"Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking."
J. Biol. Chem. 277:30219-30226(2002) [PubMed] [Europe PMC] [Abstract]

"Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis."
Mol. Cell. Biol. 22:7512-7523(2002) [PubMed] [Europe PMC] [Abstract]

"p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration."
J. Biol. Chem. 278:35636-35643(2003) [PubMed] [Europe PMC] [Abstract]

"Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems."
Am. J. Physiol. 289:C444-C454(2005) [PubMed] [Europe PMC] [Abstract]

"Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."
J. Immunol. 180:3485-3491(2008) [PubMed] [Europe PMC] [Abstract]

"Signaling network of the Btk family kinases."
Oncogene 19:5651-5661(2000) [PubMed] [Europe PMC] [Abstract]

"The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species."
Bioessays 23:436-446(2001) [PubMed] [Europe PMC] [Abstract]

"Tec kinases, actin, and cell adhesion."
Immunol. Rev. 218:45-64(2007) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the human BMX SH2 domain and of the BTK motif of human cytoplasmic tyrosine-protein kinase BMX."
Submitted (OCT-2007) to the PDB data bank

"Solution structure of the human bmx SH2 domain."
Submitted (FEB-2009) to the PDB data bank

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]