Major Facilitator Superfamily Domain Containing Protein 2A (MFSD2A)

MFSD2; NLS1; Sodium-dependent lysophosphatidylcholine symporter 1

SPN	J873
HGNC	25897
MGI	1923824
PubMed	20236515
RGD	1310174
UniProt	Q8NA29
Wiki	MFSD2

Mfsd2a, a novel mammalian major facilitator superfamily domain-containing protein, and an additional closely related protein, Mfsd2b. Most intron/exon junctions are conserved between the two genes, suggesting that they are derived from a common ancestor. Mfsd2a and Mfsd2b share a 12 transmembrane alpha-helical domain structure that bears greatest similarity to that of the bacterial Na(+)/melibiose symporters.Mfsd2a is expressed in many tissues and is highly induced in liver and BAT during fasting. Mfsd2a displays an oscillatory expression profile in BAT and liver, consistent with a circadian rhythm. Although the basal level of Mfsd2a expression is relatively low in mouse BAT, it is greatly induced during cold-induced thermogenesis and after treatment with betaAR agonists.

Reference

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]

"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis."
Biochem. J. 416:347-355(2008) [PubMed] [Europe PMC] [Abstract]

"A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2."
Proc. Natl. Acad. Sci. U.S.A. 105:17532-17537(2008) [PubMed] [Europe PMC] [Abstract]

"A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin."
Proc. Natl. Acad. Sci. U.S.A. 108:11756-11765(2011) [PubMed] [Europe PMC] [Abstract]

"MFSD2a, the Syncytin-2 receptor, is important for trophoblast fusion."
Placenta 34:85-88(2013) [PubMed] [Europe PMC] [Abstract]