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Aldose Reductase Like Protein 1 (ARL1)

AKR1B10; AKR1B12; HIS; HSI; ALDRLn; Aldo-Keto Reductase Family 1,Member B10; Aldose Reductase-Related Protein; Small Intestine Reductase

Aldose reductase (AR) is an NADPH-dependent enzyme that was first identified by its ability to reduce glucose to sorbitol. The deduced 316-amino acid AKR1B10 protein shares 71% amino acid identity with AR. Northern blot analysis revealed that AKR1B10 is overexpressed in 54% of HCCs, while AR is overexpressed in 29% of HCCs. Northern blot analysis of normal tissues showed that unlike the ubiquitously expressed AR, AKR1B10 is expressed most abundantly in small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle. AR and ARL1 reduce a similar spectrum of aromatic and aliphatic aldehyde substrates.Highest expression of AKR1B10 in adrenal gland, with modest expression in stomach, placenta, small intestine, and pancreas, and lower expression in all other tissues tested.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins J803Hu01 Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies MJ803Hu21 Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
PJ803Hu01 Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits KEJ803Hu ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Aldose Reductase Like Protein 1 (ARL1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Aldose Reductase Like Protein 1 (ARL1) Bioactivity
Antibodies NONE Monoclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Aldose Reductase Like Protein 1 (ARL1) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Aldose Reductase Like Protein 1 (ARL1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Aldose Reductase Like Protein 1 (ARL1) CLIA assay for Antigen Detection

Reference

"Identification and characterization of a novel human aldose reductase-like gene."
J. Biol. Chem. 273:11429-11435(1998) [PubMed] [Europe PMC] [Abstract]

"Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family."
Biochim. Biophys. Acta 1399:198-202(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"New member of aldose reductase family proteins overexpressed in human hepatocellular carcinoma."
Hepatology 27:943-950(1998) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Aldo-keto reductase family 1, member B10 is secreted through a lysosome-mediated non-classical pathway."
Biochem. J. 438:71-80(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10."
Proc. Natl. Acad. Sci. U.S.A. 104:20764-20769(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]