ATPase, Na+/K+ Transporting Beta 4 Polypeptide (ATP1b4)

X,K-ATPase subunit beta-m; X/potassium-transporting ATPase subunit beta-m

SPN	J774
HGNC	808
MGI	1915071
PubMed	23651441
RGD	620994
UniProt	Q9UN42

ATP1b4 has been found in all vertebrate genomes sequenced to date. However, this gene has undergone a change in function in placental mammals compared to other species. Specifically, in fish, avian, and amphibian species, this gene encodes plasma membrane-bound beta-subunits of Na,K-ATPase. In placental mammals, the encoded protein interacts with the nuclear transcriptional coregulator SKIP and may be involved in the regulation of TGF-beta signaling. Two transcript variants encoding different isoforms have been found for this gene.

Expression of ATP1B4 genes is brain-specific in teleost fishes, whereas it is predominantly muscle-specific in tetrapods. The encoded beta m-proteins in fish, amphibian, and avian species are beta-subunits of Na,K-ATPase located in the plasma membrane.

Reference

"Identification of a novel gene of the X,K-ATPase beta-subunit family that is predominantly expressed in skeletal and heart muscles."
FEBS Lett. 456:243-248(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Accumulation of beta (m), a structural member of X,K-ATPase beta-subunit family, in nuclear envelopes of perinatal myocytes."
Am. J. Physiol. 286:C757-C767(2004) [PubMed] [Europe PMC] [Abstract]

"Evolution of Na,K-ATPase betam-subunit into a coregulator of transcription in placental mammals."
Proc. Natl. Acad. Sci. U.S.A. 104:11215-11220(2007) [PubMed] [Europe PMC] [Abstract]