MOCO Sulphurase C-Terminal Domain Containing Protein 1 (MOSC1)

Molybdenum Cofactor Sulphurase C-Terminal Domain Containing Protein; Mitochondrial amidoxime-reducing component 1

SPN	J744
HGNC	26189
MGI	1913362
PubMed	21942410
RGD	1592219
UniProt	Q5VT66
Wiki	MOSC1

MOSC1 has been reported to reduce amidoximes to amidines. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms such as the bacterial YiiM proteins, or fused to other domains such as a NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters. The identification of this domain may clarify the mechanism of biogenesis of various metallo-enzymes including Molybdenum cofactor-containing enzymes that are compromised in human type II xanthinuria.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs."
J. Med. Chem. 51:8173-8177(2008) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Reduction of N(omega)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)."
Biochem. J. 433:383-391(2011) [PubMed] [Europe PMC] [Abstract]

"The mitochondrial amidoxime-reducing component (mARC1) is a novel signal-anchored protein of the outer mitochondrial membrane."
J. Biol. Chem. 287:42795-42803(2012) [PubMed] [Europe PMC] [Abstract]

"Functional characterization of protein variants encoded by non-synonymous SNPs in MARC1 and MARC2 in healthy Caucasians."
Drug Metab. Dispos. 42:718-725(2014) [PubMed] [Europe PMC] [Abstract]