Potassium Inwardly Rectifying Channel Subfamily J, Member 5 (KCNJ5)

Kir3.4; CIR; KATP1; GIRK4; G protein-activated inward rectifier potassium channel 4; Cardiac inward rectifier; Inward rectifier K(+) channel Kir3.4; Heart KATP channel

SPN	J649
HGNC	6266
MGI	104755
PubMed	24037882
RGD	61971
UniProt	P48544
Wiki	KCNJ5

KCNJ5 is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. Girk4 associated with Girk1 during or shortly after subunit synthesis and allowed appropriate glycosylation of the Girk1 subunit to a form seen in native atrial tissue. The C terminus of Girk4 was required for cell surface localization. Girk1 appeared intracellular in atrial myocytes isolated from Girk4-knockout mice, and it was not maturely glycosylated, supporting an essential role for GIRK4 in processing and cell surface localization of GIRK1/GIRK4 channels in vivo.

Reference

"Cloning and functional expression of a rat heart KATP channel."
Nature 370:456-459(1994) [PubMed] [Europe PMC] [Abstract]

Erratum
Nature 378:792-792(1995) [PubMed] [Europe PMC] [Abstract]

"A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels."
J. Neurosci. 16:930-938(1996) [PubMed] [Europe PMC] [Abstract]

"Co-expression of human Kir3 subunits can yield channels with different functional properties."
Cell. Signal. 11:871-883(1999) [PubMed] [Europe PMC] [Abstract]

"Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel."
Recept. Channels 3:299-315(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

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Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension."
Science 331:768-772(2011) [PubMed] [Europe PMC] [Abstract]

"Identification of a Kir3.4 mutation in congenital long QT syndrome."
Am. J. Hum. Genet. 86:872-880(2010) [PubMed] [Europe PMC] [Abstract]

"KCNJ5 mutations in European families with nonglucocorticoid remediable familial hyperaldosteronism."
Hypertension 59:235-240(2012) [PubMed] [Europe PMC] [Abstract]

"Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism."
Hypertension 59:592-598(2012) [PubMed] [Europe PMC] [Abstract]

"Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter."
PLoS ONE 7:E41926-E41926(2012) [PubMed] [Europe PMC] [Abstract]

"Hypertension with or without adrenal hyperplasia due to different inherited mutations in the potassium channel KCNJ5."
Proc. Natl. Acad. Sci. U.S.A. 109:2533-2538(2012) [PubMed] [Europe PMC] [Abstract]