Proteasome 26S Subunit, Non ATPase 6 (PSMD6)

S10; p44S10; Rpn7; PFAAP4; 26S proteasome regulatory subunit RPN7; Breast cancer-associated protein SGA-113M; Phosphonoformate immuno-associated protein 4

SPN	J581
HGNC	9564
MGI	1913663
PubMed	10723133
RGD	735127
UniProt	Q15008
Wiki	PSMD6

PSMD6, a highly conserved subunit of the 26S proteasome that exhibits similarity to the Arabidopsis fus6/cop11 family of signaling molecules. p44S10 gene copy number and mRNA expression were increased in association with segmental 1.8 - 11-fold chromosomal gains in cutaneous malignant melanoma cell lines and tumors. Likewise, malignant progression of human radial growth phase WM35 melanoma cells was associated with amplification and increased expression of endogenous p44S10, and increased expression of p44S10 was sufficient to induce proliferation of WM35 cells in vivo. The results demonstrate segmental copy number gains within chromosome 3p in cutaneous malignant melanoma and suggest that deregulation of a proteasome regulatory particle subunit may contribute to the malignant phenotype.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPJ581Hu01	Recombinant Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAJ581Hu01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IP.
Antibodies	PAJ581Hu01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IF.
Assay Kits	CLJ581Hu01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	CLIA assay for Antigen Detection
Assay Kits	ELJ581Hu01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPJ581Mu01	Recombinant Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAJ581Mu01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IP.
Antibodies	PAJ581Mu01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IF.
Assay Kits	CLJ581Mu01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	CLIA assay for Antigen Detection
Assay Kits	ELJ581Mu01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPJ581Ra01	Recombinant Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAJ581Ra01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IP.
Antibodies	PAJ581Ra01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IF.
Assay Kits	CLJ581Ra01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	CLIA assay for Antigen Detection
Assay Kits	ELJ581Ra01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPJ581Ca01	Recombinant Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAJ581Ca01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IP.
Antibodies	PAJ581Ca01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IF.
Assay Kits	CLJ581Ca01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	CLIA assay for Antigen Detection
Assay Kits	ELJ581Ca01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPJ581Po01	Recombinant Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAJ581Po01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IP.
Antibodies	PAJ581Po01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IF.
Assay Kits	CLJ581Po01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	CLIA assay for Antigen Detection
Assay Kits	ELJ581Po01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPJ581Bo01	Recombinant Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAJ581Bo01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IP.
Antibodies	PAJ581Bo01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IF.
Assay Kits	CLJ581Bo01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	CLIA assay for Antigen Detection
Assay Kits	ELJ581Bo01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPJ581Rb01	Recombinant Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAJ581Rb01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IP.
Antibodies	PAJ581Rb01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IF.
Assay Kits	CLJ581Rb01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	CLIA assay for Antigen Detection
Assay Kits	ELJ581Rb01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPJ581Mo01	Recombinant Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAJ581Mo01	Monoclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IP.
Antibodies	PAJ581Mo01	Polyclonal Antibody to Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	WB; IHC; ICC; IF.
Assay Kits	CLJ581Mo01	CLIA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	CLIA assay for Antigen Detection
Assay Kits	ELJ581Mo01	ELISA Kit for Proteasome 26S Subunit, Non ATPase 6 (PSMD6)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"The p44S10 locus, encoding a subunit of the proteasome regulatory particle, is amplified during progression of cutaneous malignant melanoma."
Oncogene 19:1419-1427(2000) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
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BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mass spectrometric characterization of the affinity-purified human 26S proteasome complex."
Biochemistry 46:3553-3565(2007) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]