Protease, Serine 23 (PRSS23)

SPUVE; SIG13; ZSIG13; Putative secreted protein Zsig13

SPN	J373
HGNC	14370
MGI	1923703
PubMed	23978611
RGD	1359545
UniProt	O95084
Wiki	PRSS23

PRSS23 encodes a member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels after ovulation was induced. This gene seems to be highly conserved in vertebrates and may be an important ovarian protease. PRSS23 is associated with cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS23 as well as pharmaceutical compositions comprising such compounds. The invention also provides PRSS23 as a biomarker for diseases such as cardiovascular diseases, hematological diseases, neurological diseases, cancer, endocrinological diseases, and urological diseases.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	J373Hu01	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	MJ373Hu21	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	PJ373Hu01	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	KEJ373Hu	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Protease, Serine 23 (PRSS23)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Protease, Serine 23 (PRSS23)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Protease, Serine 23 (PRSS23)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Protease, Serine 23 (PRSS23)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Protease, Serine 23 (PRSS23)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Protease, Serine 23 (PRSS23)	CLIA assay for Antigen Detection

Reference

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]