Reactive Oxygen Species Modulator 1 (ROMO1)

C20orf52; MTGMP; Glyrichin; Mitochondrial Targeting GXXXG Protein; Epididymis tissue protein Li 175; Protein MGR2 homolog

SPN	J202
HGNC	16185
MGI	1914317
PubMed	24473195
RGD	1587111
UniProt	P60602

The main source of ROS is known to be the mitochondria, and increased levels of ROS from the mitochondria have been observed in many cancer cells. Thus far, the mechanism of ROS production in cancer cell proliferation in the mitochondria is not well-understood. Romo1 increased expression of Romo1-triggered ROS production in the mitochondria. The experiments conducted in the present study showed that Romo1-derived ROS were indispensable for the proliferation of both normal and cancer cells. Furthermore, whilst cell growth was inhibited by blocking the ERK pathway in cells transfected with siRNA directed against Romo1, the cell growth was recovered by addition of exogenous hydrogen peroxide. The results of this study suggest that Romo1-induced ROS may play an important role in redox signaling in cancer cells.

Reference

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J. Cell Sci. 122:2252-2262(2009) [PubMed] [Europe PMC] [Abstract]

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Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel protein, Romo1, induces ROS production in the mitochondria."
Biochem. Biophys. Res. Commun. 347:649-655(2006) [PubMed] [Europe PMC] [Abstract]

"Drug resistance to 5-FU linked to reactive oxygen species modulator 1."
Biochem. Biophys. Res. Commun. 359:304-310(2007) [PubMed] [Europe PMC] [Abstract]

"A critical role for Romo1-derived ROS in cell proliferation."
Biochem. Biophys. Res. Commun. 369:672-678(2008) [PubMed] [Europe PMC] [Abstract]

"Replicative senescence induced by Romo1-derived reactive oxygen species."
J. Biol. Chem. 283:33763-33771(2008) [PubMed] [Europe PMC] [Abstract]

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BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

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J. Pept. Sci. 18:97-104(2012) [PubMed] [Europe PMC] [Abstract]

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Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]