Cancerous Inhibitor Of PP2A (CIP2A)

p90; KIAA1524

SPN	I931
HGNC	29302
MGI	2146335
PubMed	24493623
RGD	1310335
UniProt	Q8TCG1
Wiki	KIAA1524

CIP2A has a calculated molecular mass of 102.2 kD and has a 255-amino acid coiled-coil region at its C terminus. Immunohistochemical analysis of human and mouse cells detected diffuse cytoplasmic p90 staining, with a slight concentration in the perinuclear region. Expression was high in embryonic day-17.5 and -18.5 mouse liver, and was moderate in embryonic brain, muscle, and epidermal layers. However, p90 was not expressed in adult mouse liver. KIAA1524 gene contains at least 26 exons and spans 92 kb. The 5-prime UTR is GC rich, and the 3-prime UTR contains 2 polyadenylation signals.anti-p90 autoantibodies in HCC, gastric cancer, and esophageal cancer patients. Expression of p90 was elevated in 6 of 11 gastric cancer tissues examined.

Reference

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"Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens."
Prostate 63:252-258(2005) [PubMed] [Europe PMC] [Abstract]

"CIP2A inhibits PP2A in human malignancies."
Cell 130:51-62(2007) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

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Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

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BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]