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Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3)

HELIC1; RNAH; ASC1p200; RNA Helicase Family; Helicase, ATP Binding 1; Trip4 complex subunit p200; ASC-1 complex subunit p200

ASCC3 belongs to the helicase family. Enhances NF-kappa-B, SRF and AP1 transactivation.ASC-1 harbors an autonomous transactivation domain that contains a putative zinc finger motif which provides binding sites for basal transcription factors TBP and TFIIA,SRC-1 and CBP-p300, and nuclear receptors, as demonstrated by the glutathione S-transferase pull-down assays and the yeast two-hybrid tests. The ASC-1 binding sites involve the hinge domain but not the C-terminal AF2 core domain of nuclear receptors. Nonetheless, ASC-1 appears to require the AF2-dependent factors to function, as suggested by the ability of ASC-1 to coactivate nuclear receptors, either alone or in cooperation with SRC-1 and p300, as well as its inability to coactivate a mutant receptor lacking the AF2 core domain.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPI802Hu01 Recombinant Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAI802Hu01 Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IP.
PAI802Hu01 Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IF.
Assay Kits CLI802Hu01 CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) CLIA assay for Antigen Detection
ELI802Hu01 ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPI802Mu01 Recombinant Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAI802Mu01 Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IP.
PAI802Mu01 Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IF.
Assay Kits CLI802Mu01 CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) CLIA assay for Antigen Detection
ELI802Mu01 ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPI802Ra01 Recombinant Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAI802Ra01 Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IP.
PAI802Ra01 Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IF.
Assay Kits CLI802Ra01 CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) CLIA assay for Antigen Detection
ELI802Ra01 ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPI802Ca01 Recombinant Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAI802Ca01 Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IP.
PAI802Ca01 Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IF.
Assay Kits CLI802Ca01 CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) CLIA assay for Antigen Detection
ELI802Ca01 ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPI802Po01 Recombinant Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAI802Po01 Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IP.
PAI802Po01 Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IF.
Assay Kits CLI802Po01 CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) CLIA assay for Antigen Detection
ELI802Po01 ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPI802Bo01 Recombinant Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAI802Bo01 Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IP.
PAI802Bo01 Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IF.
Assay Kits CLI802Bo01 CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) CLIA assay for Antigen Detection
ELI802Bo01 ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPI802Rb01 Recombinant Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAI802Rb01 Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IP.
PAI802Rb01 Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IF.
Assay Kits CLI802Rb01 CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) CLIA assay for Antigen Detection
ELI802Rb01 ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPI802Mo01 Recombinant Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAI802Mo01 Monoclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IP.
PAI802Mo01 Polyclonal Antibody to Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) WB; IHC; ICC; IF.
Assay Kits CLI802Mo01 CLIA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) CLIA assay for Antigen Detection
ELI802Mo01 ELISA Kit for Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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"DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation."
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