Keratin 28 (KRT28)

KRT25D; K28; K25D; Cytokeratin-28; Type I inner root sheath-specific keratin-K25irs4; Keratin, type I cytoskeletal 28

SPN	I465
HGNC	30842
MGI	1918093
PubMed	16874310
RGD	1309530
UniProt	Q7Z3Y7
Wiki	KRT28

KRT28encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21.

Strongly expressed in skin and scalp, and weak expression observed in thymus. In the hair follicle, expressed in Henle layer, Huxley layer and in the irs cuticle. Expression extends from the bulb region up to the point of differentiation into the three layers. Also present in the medulla of beard hair (at protein level).

Reference

"The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain."
Differentiation 72:527-540(2004) [PubMed] [Europe PMC] [Abstract].

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle."
J. Invest. Dermatol. 126:2377-2386(2006) [PubMed] [Europe PMC] [Abstract]